NFKB1 and colitis: The previous research of our group shown that the lack of Cyclophilin J (CypJ) caused the loss of its protective effect in mouse colitis induced by dextransulfatesodium (DSS), and this is related to the ability of CypJ blocking the binding of ubiquitin chains, thereby negatively regulating nuclear factor kappa B (NF-κB) signaling 113.