In the study of Chunxian Zhou et al., it was also found that the opening of mPTP stimulated by icariin (ICT, a chemotherapeutic drug), was induced by JNK activation pathway 173, suggesting that JNK signaling pathway may be one of the regulatory mechanisms of CypD involved in chemotherapy-induced CRC cell necrosis (Figure 2). The gene discussed is MAPK8; the disease is colorectal carcinoma.