Their sesults showed that CypB regulated angiogenesis though hypoxia inducible factor-1α (HIF-1α)-mediated vascular endothelial growth factor (VEGF), and protected tumor cells including liver cancer and colon cancer cells from stress-induced apoptosis, including hypoxia and cisplatin-induced stress 152 (Figure 4). This evidence concerns the gene PPIB and colonic neoplasm.