Interestingly, Yeonghwan Kim's team also studied the relationship between CypB expression and tumor progression, but did not find any relevance between CypB overexpression and the grade or development of colon cancer 152, which seems to be in contradiction with the previous researches that found the expression of CypB in CRC with lymph node metastasis was significantly increased 156. Here, PPIB is linked to metastatic malignant neoplasm in the lymph nodes.