Previous studies have found that CypJ interacted with the Npl4 zinc finger (NZF) domain of TGF-β-activated kinase 1 binding protein 2/3 and the components of linear ubiquitin chain assembly complexes, blocking the ubiquitin chain binding, negatively regulating NF-κB signaling, thereby inhibiting DSS-induced colitis 113. This evidence concerns the gene PPIL3 and colitis.