The results showed that tumor suppressor gene p53 wild-type (p53WT) up-regulated the mRNA and protein levels of CypB, and overexpressed CypB interacted with ubiquitin E3 ligase (MDM2), so as to make p53WT ubiquitination degradation and short its half-life, thus inhibiting oxaliplatin-induced apoptosis of CRC cells (Figure 4). The gene discussed is PPIB; the disease is colorectal carcinoma.