DKK3 and osteosarcoma: Our functional gain and loss experiments in the osteosarcoma cells further revealed that by down-regulating the DKK3 expression, miR-214-3p promoted active β-catenin accumulation and then nuclear translocation, which further activates the translation of LEF1 in nuclear, causing Wnt/β-catenin signaling activation in osteosarcoma cells, thus to promote oncogenesis and metastasis of osteosarcoma.