However, the above mentioned molecular changed and inhibited effects on osteosarcoma progression caused by cantharidin were partially reversed by either addition of CHIR99021 or miR-214-3p over-expression, indicating specific contribution of the miR-214-3p/DKK3/GSK-3β/β-catenin/LEF1 axis in cantharidin inhibited osteosarcoma progression. Here, LEF1 is linked to osteosarcoma.