Not surprisingly, WES has identified a large number of genetic variants relevant to asthenozoospermia, while each variant is likely responsible for just a small fraction of patients, particularly including ADCY1053, CATSPER1-454, EIF4G155, GALNTL556, NSUN757, PLA2G654, SPAG1758, and TRPC559 (Table 1). The gene discussed is CATSPER1; the disease is Reduced sperm motility.