In a study, miR-129-3p directly inhibited the expression of SUMO-activated enzyme subunit 1 (SAE1) by targeting 3'UTR and also suppressed the zoylation of XRCC4, leading to more DNA damage in gastric cancer cells and inhibition of the proliferation, migration and invasion of gastric cancer cells 63. The gene discussed is XRCC4; the disease is gastric cancer.