SPP1 and osteomalacia: The increased CA-β-Cat level in osteocytes led to an osteomalacia phenotype very similar as observed in Dmp1 KO and Hyp mice, including a great increase in osteoid within the entire long bone (Figure 9a, right), high levels of type I collagen production (Figure 9b, right), an increase in BrdU+ cells (Figure 9c, right), and drastic increments of Ob markers such as OSX, OPN, and E11 (Figure 9d, right).