Then, we showed that GSDMB could bind to STAT3 and elevate the phosphorylation of STAT3, which may be the mechanism underlying the transcriptional increase of the expression of glucose metabolism-related genes (e.g., HK2, LDHA, ENO2, and IGFBP3) and the promotion of cancer cell proliferation in bladder cancer by GSDMB. Here, HK2 is linked to urinary bladder cancer.