AGER and Myocardial fibrosis: Interestingly, RAGE deletion does not influence the physiological increase of CMs hypertrophy and LV wall thickness, which were comparable to WT animals across all the age groups (Figure S1), but clearly affected myocardial fibrosis (Figure 2B-D) suggesting that exacerbation of age-dependent LV remodeling may be due to an altered activity of CFs.