Notably, data mining analysis of TCGA and several GEO datasets in the cohort of breast cancer patients who received TAM monotherapy revealed that high Cx43 expression was highly associated with improved outcome in relapse free survival (Fig. 1J and K, Fig. 2), suggesting that Cx43 may serve as a potential prognostic marker for the therapeutic response to TAM treatment. The gene discussed is GJA1; the disease is breast cancer.