Furthermore, FIP200 knockout macrophages produced much less IFNβ after the infection of SeV and IAV, but not the d109 mutant of human herpes simplex virus type 1 (HSV-1) in which the IFN-suppression viral genes are deleted25 (Fig. 4g, h, Supplementary Fig. 3e). Here, RB1CC1 is linked to infection.