Besides CdLS, this phenomenon has been also described for other chromatinopathies, including Rubinstein–Taybi Syndrome (CREBBP)42,43, Wiedemann–Steiner Syndrome (KMT2A)26 or Coffin–Siris Syndrome (ARID1A)44. The gene discussed is CREBBP; the disease is Coffin-Siris syndrome.