To answer these questions, we first evaluated whether ACh-induced vasodilation is impaired in coronary arterioles in atherosclerosis, and then we determined whether exercise training could improve coronary function by modulating the ER stress and UCP2 pathways, including the TXNIP/NLRP3 inflammasome cascade and oxidative stress response in atherosclerosis. This evidence concerns the gene UCP2 and atherosclerosis.