The observed difference between non-IHD and IHD is unlikely to be explained by the small age difference between the two groups of patients, especially since no significant difference was obtained between age groups (patients aged 50–65 vs. those aged > 65) within the same clinical condition (either non-IHD or IHD) for the level of TRPM6 and TRPM7 measured by immunofluorescence and by ELISA (see Supplementary Table S8). This evidence concerns the gene TRPM6 and myocardial ischemia.