COL1A2 is type I collagen Protein α-2 (I) chain, type I collagen is the main component of extracellular matrix (ecm), and some studies have found that compared with precancerous lesions, COL1A2 in gastric cancer group may be significantly up-regulated, and it may be used as a marker for gastric cancer prediction and early cancer determination21. Here, COL1A2 is linked to gastric cancer.