For instance, downregulated hsa-miR-1275 exhibited pairing with 30 upregulated mRNAs associated with apelin cardiac fibroblast signaling pathway, actin cytoskeleton signaling, dendritic cell maturation, adipogenesis pathway, HOTAIR regulatory, cardiac hypertrophy signaling (enhanced), breast cancer regulation by Stathmin1, axonal guidance signaling, cAMP-mediated signaling, cardiac β-adrenergic signaling and protein kinase A Signaling. This evidence concerns the gene APLN and breast cancer.