A recent large-scale study utilizing organoids derived from gastroenteropancreatic neuroendocrine (GEP) neoplasms also revealed similar genomic landscapes and (mutually exclusive) enrichment for drivers such as TP53, RB1, APC, and MYC within NEC for GEP-NEN organoids and chromosome-wide loss of heterozygosity within both NET and NEC tissues64. The gene discussed is RB1; the disease is neuroendocrine carcinoma.