These include the associations with midgut-derived NET (CDKN1B)10,13, lung NET (FHIT)56–58, pNET (TP53, MEN1, ATRX, DAXX and SETD2)3–5,7,15 and NEC (TP53, KRAS, MYC, APC and RB1, and chromothripsis)17,18,59,60. The gene discussed is RB1; the disease is neuroendocrine carcinoma.