As an example, the synergistically efficacious combination of dexamethasone (agonist of the glucocorticoid receptor) and mk-8669 (PI3K/mTOR dual inhibitor) in a colorectal adenocarcinoma cell-line is masked by HSA due to antagonistic potency (Fig. 3I). The gene discussed is MTOR; the disease is colorectal adenocarcinoma.