To experimentally dissect the role of KIF4A in prostate cancer, we tested whether KIF4A expression was required for prostate cancer cell proliferation and or survival in both AR-dependent (LNCaPi, C42Bi, and 22Rv1i) and AR-independent (PC3i and DU145i) cell-line models. The gene discussed is KIF4A; the disease is Familial prostate cancer.