KIF4A and Familial prostate cancer: To test the model that KIF4A is a prostate-specific driver gene, we generated a panel of diverse CRISPRi non-prostate cancer cell-line models (breast: MDA-MB-231i, ovarian: OVCAR3i, lung: H358i and A549i, colon: DLD1i) (Supplementary Fig. 12A).