In primary NSCLC cells with POLRMT shRNA or KO, levels mtDNA, mitochondrial transcripts (ND1 and CYTB mRNAs) as well as mRNA expressions of subunits of mitochondrial respiratory chain complexes (COX1, UQCRC2, and NDUFB8) were significantly decreased. This evidence concerns the gene MT-CYB and non-small cell lung carcinoma.