Compared to the rimonabant groups, the TXX-1-10 groups showed a more significant inhibitory effect on the amount of Ki67 (proliferation marker)-, CD31 (endothelial cell marker)-, and HPIP-positive tumor cells, and a more significant stimulatory effect on the amount of cleaved caspase-3 (apoptosis marker)-positive tumor cells (Fig. 6D), in agreement with the results of the effects of TXX-1-10 and rimonabant on breast tumor growth in vivo. The gene discussed is MKI67; the disease is neoplasm.