Since HPIP has been reported to be an activator of focal adhesion kinase (FAK) to regulate cell adhesion and migration [14], and phosphorylation of FAK (Tyr397) and Paxillin (Ser178) promote cancer cell migration and invasion [24], we investigated whether TXX-1-10 regulates FAK and Paxillin [14]. This evidence concerns the gene PBXIP1 and cancer.