In addition to cardiovascular diseases, TG2 plays a role in a diverse set of other conditions, including celiac disease, cancers (e.g., ovarian, breast, cervical, pancreatic, colorectal, liver, lung, and skin), vascular remodeling and stiffening in the systemic vasculature, pulmonary arterial hypertension, renal fibrosis, pulmonary fibrosis, and cardiac fibrosis. Here, TGM2 is linked to cardiovascular disorder.