However, as a downstream of WTAP/IGF2BPs, forced expression of S1PR3 only partly abrogated the inhibition of colony rates and migration in WTAP KO and IGF2BPs KO cells, implying that there are other molecular mechanisms of WTAP/IGF2BPs m6A axis in RCC. This evidence concerns the gene S1PR3 and renal cell adenocarcinoma.