The pleiotropic genes were: LRRN2, MAN2A1 and EYS (SCZ and educational attainment); COL16A1, EFNA5, SHANK3 (educational attainment and gF); BRE-AS1 and LINC01378 (SCZ and BPD); CLU, MIR6843 (SCZ and Alzheimer’s disease); SFXN5, SATB2, FXP1, CKB, TRMT61A, APOPT1, (SCZ and gF); TEX41 (ADHD and educational attainment); ZMIZ2, TMEM245 and SLCO3A1 (educational attainment and gF); KCNC2, (educational attainment and neuroticism); CDH8 (ADHD and gF); TCF4 (SCZ and neuroticism). The gene discussed is COA8; the disease is early-onset autosomal dominant Alzheimer disease.