Twenty-five genes displayed independent associations with two traits: RERE, LOC102724552, GPM6A (SCZ and educational attainment); RBKS (SCZ and BPD); DLGAP2 and ERICH1-AS1 (SCZ and ADHD); GLIS3 (SCZ and neuroticism); JADE2 (educational attainment and BPD); ASTN2 (ASD and BPD); FHIT (SCZ and MDD); TEAD1 (educational attainment and subjective well-being); TENM4 and MACTOD2 (gF and BPD); EXT1 (gF and AUT); LRRC4C (gF and anorexia); CACNA1E (gF and Neuroticism); CTNNA2, LRP1B, ATXN1, SNX29, CDH2 (educational attainment and gF); ZNF385B, MIPEPP3, PHACTR3 (gF and SCZ). This evidence concerns the gene ASTN2 and major depressive disorder.