To model the p53 response to oncogenic stress, we utilized a panel of cancer cell lines isolated from the K-rasLA2-G12D/+; p53LSL/LSL; Rosa26-CreERT2 (KPR) mouse model, which is an established tool for investigating the p53 tumor suppressor pathway across different tumor types (Fig. 1A) (18, 19). The gene discussed is TP53; the disease is neoplasm.