TP53 and neoplasm: Examination of the heterogeneity within each tumor type indicated a robust p53 transcriptional signature, with variations evident between untreated samples and samples harvested at 24 h following p53 restoration (LA: PC1 44%; SA: PC1 43%; and LY: PC2 16.4%), allowing us to study the p53-dependent response to oncogenic stress across these different contexts (Fig. 1E).