A higher tumor volume on PSMA PET was associated with a lower likelihood of achieving PSA50 (odds ratio [OR], 0.41 [95% CI, 0.19–0.87]; P = 0.02) and shorter OS (HR, 2.18 [95% CI, 1.36–3.51]; P = 0.001). Here, FOLH1 is linked to neoplasm.