When the entire patient population was considered (n = 2,005), the regional detection rates for local failure (prostate or prostate bed) (Supplemental Table 2; P < 0.001), pelvic nodal disease (Supplemental Table 3; P < 0.001), distant metastatic disease in soft tissue (Supplemental Table 4; P < 0.001), and bone (Supplemental Table 5; P < 0.001) increased significantly with PSA level. The gene discussed is KLK3; the disease is metastatic neoplasm.