Using large public data sets of CARDIoGRAMplusC4D and UK Biobank, we show a clear impact on CAD risk, underscoring the importance of even minor but lifelong Lp(a) reduction, and using the 1000 Genomes Project, we show that the genotypes of 4733G>A can be directly extracted from available sequence data, allowing replication and extension of our findings by others. Here, LPA is linked to coronary artery disorder.