Moreover, hypoxia can modulate the secretion of vesicles to increase the expression of GTPase associated with endosomes, RAB22A, and the exosome marker CD63. These exosomes in hypoxia usually contain molecules such as VEGFR2, TNFα1, β-catenin, AKT and EGFR and contribute to tumor progression, angiogenesis, immune suppression, invasion, and metastasis [224–226]. The gene discussed is AKT1; the disease is neoplasm.