Multivariable logistic regression analysis identified age ≥ 50 years, temperature < 37 °C, respiratory rate > 35 breaths/min, MAP ≤ 50 mmHg, SpO2 < 90%, albumin ≤ 2 g/dL, bilirubin ≥ 0.8 mg/dL, lactate ≥ 4.2 mmol/L, BUN ≥ 21 mg/dL, mechanical ventilation, hepatic failure and metastatic cancer (Additional file 1: Table S3). This evidence concerns the gene ALB and Hepatic failure.