Consistent with the inductive effect of EIF4A3 on circIKBKB expression as showed in above, overexpressing EIF4A3 significantly activated NF-κB signaling, as showed by increased NF-κB-luciferase activity and nuclear NF-κB level, and enhanced capability of BC cell to induce osteoclastogenesis, as indicated by elevated M-CSF and GM-CSF expression and the number of TRAP+-cells (Fig. 6f-i and Fig. S7c, d). Here, ACP5 is linked to breast cancer.