Hyperactivation of nuclear factor kappa B (NF-κB) signaling has been reported to be involved in cancer bone-metastasis via upregulation of multiple bone-remodeling factors, such as RANKL, parathyroid hormone-related protein preproprotein (PTHrP), macrophage colony stimulating factor (M-CSF) and granulocyte–macrophage colony stimulating factor (GM-CSF) [14–18]. The gene discussed is NFKB1; the disease is cancer.