qPCR analysis revealed that among total 25 bone remodeling factors, the mRNA levels of M-CSF and GM-CSF, which are also downstream targets of NF-κB, were significantly increased in circIKBKB-overexpressing BC cells but decreased in circIKBKB-silenced cells, compared to control cells, respectively (Fig. 5a and Fig. S6a). This evidence concerns the gene NFKB1 and breast cancer.