However, the conjugation of these toxins with CAIs of the sulphonamide type as “warheads,” through oligopeptide linkers as shown in Figure 11, led to dual agents which showed effective anticancer effects due to the action of the delivered cytotoxin only within tumour cells, as well as due to the inhibition CA IX and XII, which, as mentioned above, are tumour-associated and are present in low amounts in normal tissues, thus interfering with the metabolism and pH regulation in tumours20–22,.58–63. The gene discussed is CA9; the disease is neoplasm.