The pathway analysis of 214 mRNAs involved in the magenta module showed that they were mainly rich in mineral absorption (ko04978), malaria (ko05144), and MAPK signaling pathways (hsa04010), while the 623 mRNAs in the yellow module were mainly enriched in the cell cycle (hsa04110), DNA Replication (ko03030) and p53 signaling pathway (ko04115), etc (Fig 3A and 3B). The gene discussed is TP53; the disease is malaria.