Although any dual combination with IM caused a decrease in proliferation (p<0.0001, IM+GD and IM+PD vs imatinib), the most effective combination was the KPM (KIT/PI3K/MAPK) inhibitor cocktail (IM+GD+PD) that reduced cell proliferation by greater than 80% in the GIST-T1/670 cell line (p<0.0001) (Fig 2, top row). This evidence concerns the gene PIK3CA and gastrointestinal stromal tumor.