KIT and gastrointestinal stromal tumor: The combination of KIT inhibitors with trametinib also showed a significant increase in caspase activity (p<0.0001) and the KPM inhibitor cocktail was the most potent in inducing apoptosis in the GIST-T1/10R cell line when PD was replaced with trametinib (p<0.0001, SU+GD+PD vs. SU +PD; p<0.0001, RE+GD+PD vs. RE +PD) (S4B Fig).