In a dose response study in GIST882, 100 nM of imatinib was not sufficient to completely inhibit p-KIT (S1C Fig) and no significant difference in colony outgrowth was observed at 100 nM or 1 μM of imatinib in GIST-T1 (S1D Fig). The gene discussed is KIT; the disease is gastrointestinal stromal tumor.