Targeting of GIST with PI3K and MAPK pathway inhibitors (KPM inhibitor cocktail) was even better than dual combination with KIT inhibitor and PD, leading to pronounced reduction or complete eradication of colony outgrowth in GIST-T1/670 and GIST-T1/10R cell lines. The gene discussed is PIK3CA; the disease is gastrointestinal stromal tumor.