The binding of IL-33 to its ST2 receptor activates transcription factors, via MyD88 dependent but TRIF independent pathway, and stimulates the production of Th2 cytokines such as IL-4, IL-5 and IL-13 in wild type mice, also restoring the Th2 asthma phenotype in IL-4 deficient mice [17]. The gene discussed is IL4; the disease is asthma.