NOTCH1 and coronary artery disorder: Although, several genes have been shown to be altered in syndromic and non-syndromic cases with CHD and TAA (e.g. HEY2 [36], MYH11 and NOTCH1 [37]), among the 10 genes significant in our analysis for TAA, CHD and the combined scenario, none has been reported previously to be associated with either CHD or TAA.