This TCR pairing was reminiscent of mucosal associated invariant T (MAIT) cells, a unique innate-like T cell subset, activated by conserved bacterial ligands presented by the invariant MHC MR1 molecule in host defense against bacterial and viral infections (36, 37) that can have a deleterious function in autoimmune diseases (38–40), especially when CD25 is upregulated on the cells (41). This evidence concerns the gene HLA-C and autoimmune disease.