IL2 and type 1 diabetes mellitus: In this study, single-cell analysis of differentially expressed genes in the GZMB+ NK cluster (cluster 4 in Supplemental Figure 3) between Treg-T1D and TILT samples showed limited differences at day 0 while a large set of phenotypic and activation markers of mature NK cells was altered in peripheral blood cells isolated from TILT patients at day 7 after the first course of IL-2 (Figure 5A).