MTOR and Stroke: Similarly, immunoblotting showed a marked increase in p-AMPKα, p-ULK1 (Ser 317), and active caspase-3 plus a greater reduction in p62/SQSTM1, p-mTOR, mTOR, p-S6, p-4E-BP, and p-ULK1 (Ser757) in the ipsilateral cerebral cortex of CrT–/y mice 24 hours after stroke (Figure 6, B and C).