TP53 and colorectal cancer: We tested CB002-analogs in the ChemBridge library for the capability to induce the luciferase activity using a p53-regulated luciferase reporter stably expressed in the SW480 colorectal cancer cell line and also determined the IC50 values for the compounds by a CellTiter glow cytotoxicity assay (Figure 1A–B, Figure 1—figure supplement 1).