In rapidly dividing tissues, such as ovarian cancer, hepatoma, pancreatic cancer (which are situations where there is increased expression of GPR55) and EC, GPR55 staining might also be observed in the cytoplasm, because during rapid protein synthesis and receptor turnover, GPR55 protein would be observed on ribosomes attached to the rough endoplasmic reticulum, and in vacuoles when the protein is recycled (Weinberg and Puthenveedu 2019). This evidence concerns the gene GPR55 and hepatocellular carcinoma.