These transcriptional regulators are also involved in glucose metabolism (Wallbillich et al. 2017) and interact with LPI and STAT3, factors that are also known to be a control point in obesity progression (Chang et al. 2015; Arifin and Falasca 2016), which in turn has a strong relationship to the development and progression of EC (Onstad et al. 2016). This evidence concerns the gene STAT3 and obesity due to melanocortin 4 receptor deficiency.