Compared with the control group, the expression of PCNA, CD34 and PATK protein in the transplanted tumor tissue of the IGF group was up-regulated (P < 0.05), while the expression of PCNA, CD34 and PATK protein in the transplanted tumor tissue of the P group, the LY group and the P + LY group Decrease (P < 0.05). This evidence concerns the gene PCNA and neoplasm.