To identify the material basis responsible for the antifibrosis effect of CKI, we further explored the influence of four identified alkaloids and Mimic on the activation and fibrosis of LX‐2 cells (Table S1), including matrine (M), oxymatrine (OM), sophocarpine (S), oxysophocarpine (OS) and Mimic (M+OM+S+OS). Here, CHKA is linked to ocular melanoma.