The upregulation of S100A7 mRNA was subsequently verified in three independent RNA microarrays (GSE43624, GSE53622, and GSE23400), which comprised 119, 60, and 53 pairs of human ESCC and adjacent normal tissues, respectively19, 20 (Figure 1C‐E). The gene discussed is S100A7; the disease is esophageal squamous cell carcinoma.