Our results revealed that intracellular S100A7 plays an oncogenic role in ESCC by activating cell proliferation and promoting metastasis, which is consistent with previous findings in breast invasive carcinoma (BRCA), oral squamous cell carcinoma (OSCC), and nonsmall cell lung cancer cells (NSCLC).18, 37. Here, S100A7 is linked to invasive breast carcinoma.