Our RNA‐seq results showed that IL6‐AS1 was significantly positively correlated with IL‐6, and miR‐149‐5p was significantly negatively correlated with IL‐6 and IL6‐AS1 (Figure 8H), the gene expression changes in COPD were consistent with the regulatory mechanisms of ceRNA, and mutual positive correlation was demonstrated by IL6‐AS1/IL‐6, IL6‐AS1/EBF1, and IL‐6/EBF1 in lung tissue. This evidence concerns the gene EBF1 and chronic obstructive pulmonary disease.