Through a high‐throughput sequencing of samples, the expression of hundreds of lncRNAs vary considerably between COPD patients and smokers with non‐COPD and notably that the lncRNA COPDA1 is significant highly expressed in COPD and facilitates proliferation of human bronchial smooth muscle cells by regulating membrane spanning four domains A1.19 The gene discussed is COPDA1; the disease is chronic obstructive pulmonary disease.