CA4 and neoplasm: constructed a polypeptide‐based nano‐vehicle which fulfilled the combined antitumor treatment by released Pt drug and generated sufficient •OH, meanwhile used for T2‐weighted MRI of tumor.[224] CA4 represents a critical vascular disrupting strategy for tumor therapy, but the anti‐polymerization effect of CA4 on tubulin is reversible and its rapid biological clearance has compromised its overall therapeutic efficiency.