Finally, to test whether the synergistic effects of JAK1 inhibitors and docetaxel in PCa cells is dependent on STAT3 or PI3K/AKT signalling, we ectopically expressed a constitutively active STAT3 or a myristoylated AKT in DU145 and PC3 cells followed by docetaxel treatment in the presence or absence of baricitinib. Here, AKT1 is linked to posterior cortical atrophy.