Of all APCs, dendritic cells are also capable of cross-presenting (transporting externally-acquired peptides into the cytoplasm for proteasomal processing, as would be required for MHC-I-associated peptides) MHC-I antigens to CD8 T cells [10], which is particularly important for T cell priming in the tumor microenvironment or draining lymph node. The gene discussed is CD8A; the disease is neoplasm.