CEACAM5 and colorectal cancer: Furthermore, many other clinicopathological factors, such as primary site, tumor size, lymph node ratio (LNR), pretreatment carcinoembryonic antigen (CEA) level, circumferential resection margin (CRM), and tumor deposits, have been demonstrated to influence the survival outcome in colorectal cancer, while they were not sufficiently utilized by the TNM staging system.