After controlling confounding factors, the multivariate Cox regression analysis demonstrated that race, primary site, histology, grade, tumor size, regional nodes examined, LNR, liver metastasis, lung metastasis, bone metastasis, TNM stage, T stage, CEA, perineural invasion, and median household income were independent prognostic factors of EO-CRC patients as shown in Fig. 2. The gene discussed is CEACAM5; the disease is bone metastasis.