For instance, a 45-year-old White patient (3 points) with right-sided colon (16 points) adenocarcinoma (0 points), T4 (35 points), without lung, liver, or bone metastasis (0, 0, and 0 points), TNM stage III (48 points), poor differentiated (25 points), tumor size > 5 cm (8 points), examined 12 regional lymph nodes (0 points), LNR > 0.6 (50 points), CEA positive (24 points), without perineural invasion (0 points), median household income 70,000 dollars (10 points) would have a total of 219 points, which means a predicted 3-year OS of 40.0% and predicted 5-year OS of 20.0%. The gene discussed is CEACAM5; the disease is adenocarcinoma.