IL6 and Arthritis: In addition, Chow et al. found an increased level of IL-6 was associated with persistent joint pain, while Sepúlveda-Delgado et al. suggested IL-6 could be used to predict CHIKV-induced arthritis due to the strong relationship between IL-6 levels in the acute phase and severity of joint involvement and delay in musculoskeletal symptom resolution [5,6].