Notably, the overexpression of GSTs and MRP1 has been recognized as one underlying mechanism for therapeutic resistance in various cancers (breast, colorectal, lung, ovarian, pancreatic), with overexpressed GST pi 1, a member of the GST family, showing intense correlation with CSCs-related resistance and being considered as a biomarker for cancer[56,62-65]. The gene discussed is HPGDS; the disease is cancer.