BIRC5 and hepatocellular carcinoma: In an another study, where PLR was incorporated to a PEGylated formulation of chitosan (PEG-chitosan-PLR) not only caused significant reduction in the expression of survivin via survivin-siRNA in Hepa 1–6 (mouse hepatoma), A549 (human lung carcinoma), and VK2 (human vagina endometriosis) cells and of GFP in 293-T (human embryonic kidney) GFP cells but also stands high serum tolerance (upto 50%).