A multifunctional small molecule PEI (600 Da) based nanoparticle with octyl chain modification, bioreducible linkages and detachable cross-linked hyaluronic acid (HA) shell, HA-PSR, was developed to evaluate the anti-cancerous activity of polo-like kinase 1 (PLK1) specific siRNA (PLK1-siRNA) and Paclitaxel (PTX) in lung cancer model of A549 cells in vitro and in vivo [119]. This evidence concerns the gene PLK1 and lung carcinoma.