Ramesh and coworkers [106] investigated the efficacy of folate receptor-α (FRA)-targeted DOTAP: Cholesterol lipid nanoparticles encapsulated with HuR-siRNA (HuR-FNP) against H1299 lung cancer cell line and the results were compared to normal lung fibroblast (CCD16) cells with low to no FRA expression. This evidence concerns the gene ELAVL1 and lung cancer.