In this context, Won et al [95] synthesized bioreducible poly (oligo-d-arginine) (rPOA) with two cysteines Cys-9DR-Cys and demonstrated the fast decondensation of poly(oligo-d-arginine)/VEGF-siRNA polyplexes in the cytoplasm in response to intracellular glutathione (GSH) in SCC (human squamous cell carcinoma) cells in vitro to reduce the VEGF induced secretions, mRNA levels, and angiogenesis in cancer cells. The gene discussed is VEGFA; the disease is squamous cell carcinoma.