An mRNA analysis of the human hepatocellular carcinoma GSE14520 dataset from the NCBI Gene Expression Omnibus and the human hepatocellular carcinoma dataset from the Cancer Genome Atlas program showed ADI1 mRNA level reductions in cancerous tissue with more substantial down-regulation of ADI1 in later stages of HCC progression, a correlation supported by immunohistochemistry analysis.[24]. Here, ADI1 is linked to cancer.