[37],[31, 38] MT1-MMP, also called MMP-14, functions in the pericellular space on the cell surface, where it is involved in the degradation of extracellular matrix involved in cellular functions such as migration, proliferation, and the regulation of cell morphology.[26, 39] Due to its high expression level in cancerous tissue, MT1-MMP is believed to have a significant role in tumor metastasis via degradation of the extracellular matrix, freeing tumor cells to migrate. The gene discussed is MMP14; the disease is neoplasm.